Version 5.4
Bos taurus Protein: AGTR1
Summary
InnateDB Protein IDBP-700148.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGTR1
Protein Name Type-1 angiotensin II receptor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000055053
InnateDB Gene IDBG-647315 (AGTR1)
Protein Structure
UniProt Annotation
Function Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Adrenal medulla, cortex and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001596 angiotensin type I receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004945 angiotensin type II receptor activity
GO:0005515 protein binding
GO:0031711 bradykinin receptor binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001822 kidney development
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007266 Rho protein signal transduction
GO:0010873 positive regulation of cholesterol esterification
GO:0019229 regulation of vasoconstriction
GO:0019722 calcium-mediated signaling
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032430 positive regulation of phospholipase A2 activity
GO:0038166 angiotensin-activated signaling pathway
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060326 cell chemotaxis
GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000190 Angiotensin II receptor type 1
IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR000496 Bradykinin receptor family
IPR001186 Bradykinin receptor B1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00635
PR00241
PR00237
PR00657
PR00425
PR00993
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P25104
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281607
UniGene Bt.4539
RefSeq NP_776658
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL X62294
GenPept CAA44182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca