InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MC4R

Summary

InnateDB Protein

IDBP-700783.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MC4R

Protein Name

Melanocortin receptor 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026223

InnateDB Gene

IDBG-648013 (MC4R)

Protein Structure

UniProt Annotation

Function

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP) (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004980	melanocyte-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042923	neuropeptide binding

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007631	feeding behavior
GO:0019222	regulation of metabolic process
GO:0030073	insulin secretion
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032868	response to insulin
GO:0045780	positive regulation of bone resorption

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000155 Melanocortin 4 receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001671 Melanocortin/ACTH receptor
IPR001908 Melanocortin receptor
IPR002230 Cannabinoid receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR01062
PR00237
PR00534
PR00535
PR00362

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9GLJ8