Version 5.4
Bos taurus Protein: SOCS1
Summary
InnateDB Protein IDBP-701419.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS1
Protein Name suppressor of cytokine signaling 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000005753
InnateDB Gene IDBG-648701 (SOCS1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.
Predicted by orthology
Total 79 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0019210 kinase inhibitor activity
GO:0019901 protein kinase binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0007259 JAK-STAT cascade
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0035556 intracellular signal transduction
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045444 fat cell differentiation
GO:0046426 negative regulation of JAK-STAT cascade
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001496 SOCS protein, C-terminal
PFAM PF00017
PF14633
PF07525
PRINTS PR00401
PIRSF
SMART SM00252
SM00253
SM00969
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MSN0
UniProt Splice Variant
Entrez Gene 518795
UniGene Bt.1736
RefSeq XP_002698010
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057473 GJ062847 JX155782
GenPept AFP96994 DAA15735

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca