Bos taurus Gene: SOCS1
Summary
InnateDB Gene IDBG-648701.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004386
Encoded Proteins
suppressor of cytokine signaling 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] SOCS1 is a potent and multifaceted regulator of cytokines and cell-mediated inflammation.
[Homo sapiens] SOCS1 regulates the IFN but Not NF{kappa}B Pathway in TLR-Stimulated Human monocytes and macrophages.
[Homo sapiens] SOCS1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signalling to TLR-mediated pathways controlling expression of IL12, a key cytokine linking innate and adaptive immunity.
[Homo sapiens] SOCS1 is targeted by endogenous and pharmacologic glucocorticoids to limit TLR3/TLR4-mediated STAT1 activation which results in the suppression of inflammation. (Demonstrated in murine model)
[Homo sapiens] SOCS1 inhibits type I interferon (IFN) signaling through an interaction with the IFNAR1 associated kinase, TYK2, resulting in a reduced IFN response and reduced IFNAR1 surface expression.
[Mus musculus] Socs1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signaling to Tlr-mediated pathways controlling expression of Il12, a key cytokine linking innate and adaptive immunity.
[Mus musculus] Socs1 is targeted by endogenous and pharmacologic glucocorticoids to limit Tlr3/Tlr4-mediated Stat1 activation which results in the suppression of inflammation.
[Mus musculus] Socs1 inhibits type I interferon (IFN) signaling through an interaction with the Ifnar1 associated kinase, Tyk2, resulting in a reduced IFN response and reduced Ifnar1 surface expression. (Demonstrated in human)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185338:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:9975299-9975970
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005753 ENSBTAP00000005753
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.
Predicted by orthology
Total 79 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0019210 kinase inhibitor activity
GO:0019901 protein kinase binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0007259 JAK-STAT cascade
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0035556 intracellular signal transduction
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045444 fat cell differentiation
GO:0046426 negative regulation of JAK-STAT cascade
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
KitReceptor pathway
IL2 pathway
IL4 pathway
IL5 pathway
TSH pathway
Prolactin pathway
REACTOME
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Signaling by SCF-KIT pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Regulation of IFNA signaling pathway
Signal Transduction pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Growth hormone receptor signaling pathway
Interferon gamma signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Regulation of IFNG signaling pathway
Class I MHC mediated antigen processing & presentation pathway
Regulation of KIT signaling pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Immune System pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Activated TLR4 signalling pathway
Growth hormone receptor signaling pathway
Signal Transduction pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
Ubiquitin mediated proteolysis pathway
Osteoclast differentiation pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Type II diabetes mellitus pathway
Toxoplasmosis pathway
Ubiquitin mediated proteolysis pathway
Osteoclast differentiation pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Type II diabetes mellitus pathway
Toxoplasmosis pathway
INOH
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
PID BIOCARTA
Il-2 receptor beta chain in t cell activation [Biocarta view]
PID NCI
IL2-mediated signaling events
IL12-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
IL4-mediated signaling events
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL F1MSN0
UniProt Splice Variant
Entrez Gene 518795
UniGene Bt.1736
RefSeq XM_002697964 XM_864316
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057473 GJ062847 JX155782
GenPept AFP96994 DAA15735
RNA Seq Atlas 518795
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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