Version 5.4
| Bos taurus Gene: SOCS1 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-648701.3 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | SOCS1 | ||||||||||||||||||||||
| Gene Name | Uncharacterized protein | ||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000004386 | ||||||||||||||||||||||
| Encoded Proteins |
suppressor of cytokine signaling 1
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] SOCS1 is a potent and multifaceted regulator of cytokines and cell-mediated inflammation.
[Homo sapiens] SOCS1 regulates the IFN but Not NF{kappa}B Pathway in TLR-Stimulated Human monocytes and macrophages.
[Homo sapiens] SOCS1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signalling to TLR-mediated pathways controlling expression of IL12, a key cytokine linking innate and adaptive immunity.
[Homo sapiens] SOCS1 is targeted by endogenous and pharmacologic glucocorticoids to limit TLR3/TLR4-mediated STAT1 activation which results in the suppression of inflammation. (Demonstrated in murine model)
[Homo sapiens] SOCS1 inhibits type I interferon (IFN) signaling through an interaction with the IFNAR1 associated kinase, TYK2, resulting in a reduced IFN response and reduced IFNAR1 surface expression.
[Mus musculus] Socs1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signaling to Tlr-mediated pathways controlling expression of Il12, a key cytokine linking innate and adaptive immunity.
[Mus musculus] Socs1 is targeted by endogenous and pharmacologic glucocorticoids to limit Tlr3/Tlr4-mediated Stat1 activation which results in the suppression of inflammation.
[Mus musculus] Socs1 inhibits type I interferon (IFN) signaling through an interaction with the Ifnar1 associated kinase, Tyk2, resulting in a reduced IFN response and reduced Ifnar1 surface expression. (Demonstrated in human)
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185338:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 25:9975299-9975970 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | |||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
KitReceptor pathway
IL2 pathway
IL4 pathway
IL5 pathway
TSH pathway
Prolactin pathway
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| REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Growth hormone receptor signaling pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Activated TLR4 signalling pathway
Class I MHC mediated antigen processing & presentation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Immune System pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Activated TLR4 signalling pathway
Growth hormone receptor signaling pathway
Signal Transduction pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Ubiquitin mediated proteolysis pathway
Insulin signaling pathway pathway
Jak-STAT signaling pathway pathway
Type II diabetes mellitus pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Ubiquitin mediated proteolysis pathway
Type II diabetes mellitus pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
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| INOH |
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
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| PID NCI |
IL2-mediated signaling events
IL12-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
IL4-mediated signaling events
IFN-gamma pathway
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | F1MSN0 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 518795 | ||||||||||||||||||||||
| UniGene | Bt.1736 | ||||||||||||||||||||||
| RefSeq | XM_002697964 XM_864316 | ||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | DAAA02057473 GJ062847 JX155782 | ||||||||||||||||||||||
| GenPept | AFP96994 DAA15735 | ||||||||||||||||||||||
| RNA Seq Atlas | 518795 | ||||||||||||||||||||||