InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.104022

Summary

InnateDB Protein

IDBP-701557.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.104022

Protein Name

neurogenic differentiation factor 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002301

InnateDB Gene

IDBG-648841 (BT.104022)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0003326	pancreatic A cell fate commitment
GO:0003329	pancreatic PP cell fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007263	nitric oxide mediated signal transduction
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0009749	response to glucose
GO:0009952	anterior/posterior pattern specification
GO:0021542	dentate gyrus development
GO:0021549	cerebellum development
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030073	insulin secretion
GO:0030154	cell differentiation
GO:0030902	hindbrain development
GO:0031018	endocrine pancreas development
GO:0035881	amacrine cell differentiation
GO:0035883	enteroendocrine cell differentiation
GO:0042593	glucose homeostasis
GO:0043010	camera-type eye development
GO:0043065	positive regulation of apoptotic process
GO:0045165	cell fate commitment
GO:0045597	positive regulation of cell differentiation
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046426	negative regulation of JAK-STAT cascade
GO:0048562	embryonic organ morphogenesis
GO:0048839	inner ear development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060730	regulation of intestinal epithelial structure maintenance
GO:0071156	regulation of cell cycle arrest
GO:2000675	negative regulation of type B pancreatic cell apoptotic process
GO:2000679	positive regulation of transcription regulatory region DNA binding

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
IPR022575 Neurogenic differentiation factor, domain of unknown function

PFAM

PF00010
PF12533

PRINTS

PIRSF

PIRSF015618

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt