InnateDB Protein
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IDBP-70159.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MGAT5B
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Protein Name
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mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000301618
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InnateDB Gene
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IDBG-70155 (MGAT5B)
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Protein Structure
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Function |
Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. {ECO:0000269PubMed:12941944, ECO:0000269PubMed:14617637, ECO:0000269PubMed:14623122, ECO:0000269PubMed:16606368, ECO:0000269PubMed:16857188}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in brain. Expressed in all area of the adult and fetal brain Also expressed at much lower level in testis, spleen and thymus. {ECO:0000269PubMed:12941944, ECO:0000269PubMed:14623122}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0030144
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alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR015424
Pyridoxal phosphate-dependent transferase
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3V5L5
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PhosphoSite |
PhosphoSite-Q3V5L5
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TrEMBL |
H3BR20
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UniProt Splice Variant |
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Entrez Gene |
146664
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UniGene |
Hs.144531
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RefSeq |
NP_653278
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HUGO |
HGNC:24140
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OMIM |
612441
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CCDS |
CCDS11751
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HPRD |
14392
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IMGT |
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EMBL |
AB109185
AB114297
AB235153
AC016168
AK057861
BC062354
BC063862
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GenPept |
AAH62354
AAH63862
BAB71598
BAC84969
BAD02406
BAE44474
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