InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AFMID

Summary

InnateDB Protein

IDBP-70531.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AFMID

Protein Name

arylformamidase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000328938

InnateDB Gene

IDBG-70529 (AFMID)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. {ECO:0000255HAMAP-Rule:MF_03014}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000255HAMAP- Rule:MF_03014}. Nucleus {ECO:0000255HAMAP-Rule:MF_03014}. Note=Predominantly cytosolic. Some fraction is nuclear. {ECO:0000255HAMAP-Rule:MF_03014}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004061	arylformamidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006569	tryptophan catabolic process
GO:0008152	metabolic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process