InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BIRC5

Summary

InnateDB Protein

IDBP-70560.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC5

Protein Name

baculoviral IAP repeat containing 5

Synonyms

API4; EPR-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000364086

InnateDB Gene

IDBG-70554 (BIRC5)

Protein Structure

UniProt Annotation

Function

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. {ECO:0000269PubMed:10626797, ECO:0000269PubMed:12773388, ECO:0000269PubMed:16291752, ECO:0000269PubMed:16322459, ECO:0000269PubMed:18591255, ECO:0000269PubMed:20826784, ECO:0000269PubMed:21536684, ECO:0000269PubMed:9859993}.

Subcellular Localization

Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1- mediated nuclear export.

Disease Associations

Tissue Specificity

Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines. {ECO:0000269PubMed:10626797, ECO:0000269PubMed:14741722, ECO:0000269PubMed:16329164}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.

Experimentally validated
Total	74 [view]
Protein-Protein	64 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0008536	Ran GTPase binding
GO:0015631	tubulin binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0048037	cofactor binding
GO:0050897	cobalt ion binding
GO:0051087	chaperone binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008284	positive regulation of cell proliferation
GO:0010951	negative regulation of endopeptidase activity
GO:0031503	protein complex localization
GO:0031536	positive regulation of exit from mitosis
GO:0031577	spindle checkpoint
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0051301	cell division
GO:0051303	establishment of chromosome localization

Cellular Component

GO:0000228	nuclear chromosome
GO:0000775	chromosome, centromeric region
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005814	centriole
GO:0005819	spindle
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005876	spindle microtubule
GO:0005881	cytoplasmic microtubule
GO:0030496	midbody
GO:0031021	interphase microtubule organizing center
GO:0032133	chromosome passenger complex