Homo sapiens Gene: BIRC5
Summary
InnateDB Gene IDBG-70554.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BIRC5
Gene Name baculoviral IAP repeat containing 5
Synonyms API4; EPR-1;
Species Homo sapiens
Ensembl Gene ENSG00000089685
Encoded Proteins
baculoviral IAP repeat containing 5
baculoviral IAP repeat containing 5
baculoviral IAP repeat containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
BIRC5 is cleaved by GZMM (granzyme M) and this triggers degradation of the BIRC5-XIAP complex to free caspase activity, leading to cytolysis of target cells.
Entrez Gene
Summary This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:78214186-78225636
Strand Forward strand
Band q25.3
Transcripts
ENST00000301633 ENSP00000301633
ENST00000350051 ENSP00000324180
ENST00000374948 ENSP00000364086
ENST00000590449 ENSP00000465868
ENST00000587746 ENSP00000466675
ENST00000592115
ENST00000591800 ENSP00000467259
ENST00000592734 ENSP00000466617
ENST00000586192 ENSP00000466063
ENST00000589892
ENST00000590925 ENSP00000467336
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
Experimentally validated
Total 74 [view]
Protein-Protein 64 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0008536 Ran GTPase binding
GO:0015631 tubulin binding
GO:0019899 enzyme binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0048037 cofactor binding
GO:0050897 cobalt ion binding
GO:0051087 chaperone binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0000910 cytokinesis
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007346 regulation of mitotic cell cycle
GO:0008284 positive regulation of cell proliferation
GO:0010951 negative regulation of endopeptidase activity
GO:0031503 protein complex localization
GO:0031536 positive regulation of exit from mitosis
GO:0031577 spindle checkpoint
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0051301 cell division
GO:0051303 establishment of chromosome localization
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061469 regulation of type B pancreatic cell proliferation
Cellular Component
GO:0000228 nuclear chromosome
GO:0000775 chromosome, centromeric region
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0005881 cytoplasmic microtubule
GO:0030496 midbody
GO:0031021 interphase microtubule organizing center
GO:0032133 chromosome passenger complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Pathways in cancer pathway
Colorectal cancer pathway
INOH
PID BIOCARTA
B cell survival pathway [Biocarta view]
PID NCI
Aurora A signaling
Validated targets of C-MYC transcriptional activation
Aurora B signaling
FOXM1 transcription factor network
Cross-References
SwissProt O15392
TrEMBL
UniProt Splice Variant
Entrez Gene 332
UniGene Hs.514527 Hs.606084 Hs.742107
RefSeq NM_001012271 NM_001168 NM_001012270
HUGO HGNC:593
OMIM 603352
CCDS CCDS32752 CCDS11755 CCDS32751
HPRD 04520
IMGT
EMBL AB028869 AB154416 AC087645 AF077350 AK223428 AK311917 AY795969 AY830084 AY927772 BC008718 BC034148 BC065497 CH471099 CR541740 DQ227257 DQ310375 DQ310376 DQ310377 DQ310378 DQ310379 U75285
GenPept AAC51660 AAD34226 AAH08718 AAH34148 AAH65497 AAV40840 AAW22624 AAY15202 ABB76601 ABC42341 ABC42342 ABC42343 ABC42344 ABC42345 BAA93676 BAD11155 BAD97148 BAG34858 CAG46540 EAW89514
RNA Seq Atlas 332