InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BIRC5

Summary

InnateDB Gene

IDBG-70554.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC5

Gene Name

baculoviral IAP repeat containing 5

Synonyms

API4; EPR-1;

Species

Homo sapiens

Ensembl Gene

ENSG00000089685

Encoded Proteins

IDBP-70556

baculoviral IAP repeat containing 5

IDBP-70558

baculoviral IAP repeat containing 5

IDBP-70560

baculoviral IAP repeat containing 5

IDBP-764823

IDBP-763103

IDBP-760042

IDBP-758974

IDBP-758598

IDBP-762658

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20406824

BIRC5 is cleaved by GZMM (granzyme M) and this triggers degradation of the BIRC5-XIAP complex to free caspase activity, leading to cytolysis of target cells.

Entrez Gene

Summary

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:78214186-78225636

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000301633	ENSP00000301633
ENST00000350051	ENSP00000324180
ENST00000374948	ENSP00000364086
ENST00000590449	ENSP00000465868
ENST00000587746	ENSP00000466675
ENST00000592115
ENST00000591800	ENSP00000467259
ENST00000592734	ENSP00000466617
ENST00000586192	ENSP00000466063
ENST00000589892
ENST00000590925	ENSP00000467336

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.

Experimentally validated
Total	74 [view]
Protein-Protein	64 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0008536	Ran GTPase binding
GO:0015631	tubulin binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0048037	cofactor binding
GO:0050897	cobalt ion binding
GO:0051087	chaperone binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007346	regulation of mitotic cell cycle
GO:0008284	positive regulation of cell proliferation
GO:0010951	negative regulation of endopeptidase activity
GO:0031503	protein complex localization
GO:0031536	positive regulation of exit from mitosis
GO:0031577	spindle checkpoint
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0051301	cell division
GO:0051303	establishment of chromosome localization
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061469	regulation of type B pancreatic cell proliferation

Cellular Component

GO:0000228	nuclear chromosome
GO:0000775	chromosome, centromeric region
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005814	centriole
GO:0005819	spindle
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005876	spindle microtubule
GO:0005881	cytoplasmic microtubule
GO:0030496	midbody
GO:0031021	interphase microtubule organizing center
GO:0032133	chromosome passenger complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000017716

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000013573

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_150471

Separation of Sister Chromatids pathway

REACT_682

Mitotic Prometaphase pathway

REACT_115566

Cell Cycle pathway

REACT_910

M Phase pathway

REACT_1275

Mitotic Anaphase pathway

REACT_152

Cell Cycle, Mitotic pathway

REACT_150425

Resolution of Sister Chromatid Cohesion pathway

REACT_150314

Mitotic Metaphase and Anaphase pathway

KEGG

hsa05200

Pathways in cancer pathway

hsa05210

Colorectal cancer pathway

INOH

PID BIOCARTA

100228

B cell survival pathway [Biocarta view]

PID NCI

aurora_a_pathway

Aurora A signaling

myc_activpathway

Validated targets of C-MYC transcriptional activation

aurora_b_pathway

Aurora B signaling

foxm1pathway

FOXM1 transcription factor network

Cross-References

SwissProt

O15392

TrEMBL

UniProt Splice Variant

Entrez Gene

332

UniGene

Hs.514527 Hs.606084 Hs.742107

RefSeq

NM_001012271 NM_001168 NM_001012270

HUGO

HGNC:593

OMIM

603352

CCDS

CCDS32752 CCDS11755 CCDS32751

HPRD

04520

IMGT

EMBL

AB028869 AB154416 AC087645 AF077350 AK223428 AK311917 AY795969 AY830084 AY927772 BC008718 BC034148 BC065497 CH471099 CR541740 DQ227257 DQ310375 DQ310376 DQ310377 DQ310378 DQ310379 U75285

GenPept

AAC51660 AAD34226 AAH08718 AAH34148 AAH65497 AAV40840 AAW22624 AAY15202 ABB76601 ABC42341 ABC42342 ABC42343 ABC42344 ABC42345 BAA93676 BAD11155 BAD97148 BAG34858 CAG46540 EAW89514

RNA Seq Atlas

332