InnateDB Protein
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IDBP-70569.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCNT2
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Protein Name
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cyclin T2
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Synonyms
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CYCT2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000295238
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InnateDB Gene
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IDBG-70567 (CCNT2)
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Protein Structure
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Function |
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). {ECO:0000269PubMed:10364329}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0019901
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protein kinase binding
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Biological Process |
GO:0000079
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regulation of cyclin-dependent protein serine/threonine kinase activity
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0006368
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transcription elongation from RNA polymerase II promoter
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GO:0007049
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cell cycle
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GO:0007179
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transforming growth factor beta receptor signaling pathway
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GO:0010467
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gene expression
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GO:0016032
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viral process
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051301
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cell division
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Cellular Component |
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PDB ID |
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InterPro |
IPR006671
Cyclin, N-terminal
IPR013763
Cyclin-like
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PFAM |
PF00134
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PRINTS |
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PIRSF |
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SMART |
SM00385
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TIGRFAMs |
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Modification |
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SwissProt |
O60583
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PhosphoSite |
PhosphoSite-O60583
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TrEMBL |
B4DH21
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UniProt Splice Variant |
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Entrez Gene |
905
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UniGene |
Hs.743651
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RefSeq |
NP_001232
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HUGO |
HGNC:1600
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OMIM |
603862
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CCDS |
CCDS2175
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HPRD |
04839
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IMGT |
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EMBL |
AC016725
AF048731
AF048732
AK292913
AK294889
AY865621
BC114366
CH471058
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GenPept |
AAC39665
AAC39666
AAI14367
AAW56073
AAY14998
BAF85602
BAG57982
EAX11644
EAX11645
EAX11646
EAX11647
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