InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNT2

Summary

InnateDB Protein

IDBP-70571.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNT2

Protein Name

cyclin T2

Synonyms

CYCT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000264157

InnateDB Gene

IDBG-70567 (CCNT2)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). {ECO:0000269PubMed:10364329}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0007049	cell cycle
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051301	cell division