InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL11

Summary

InnateDB Protein

IDBP-70604.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL11

Protein Name

interleukin 11

Synonyms

AGIF; IL-11;

Species

Homo sapiens

Ensembl Protein

ENSP00000264563

InnateDB Gene

IDBG-70602 (IL11)

Protein Structure

UniProt Annotation

Function

Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	6 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005142	interleukin-11 receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0030183	B cell differentiation
GO:0030219	megakaryocyte differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0043410	positive regulation of MAPK cascade
GO:0045444	fat cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046888	negative regulation of hormone secretion
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation