Version 5.4
Homo sapiens Gene: IL11
Summary
InnateDB Gene IDBG-70602.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL11
Gene Name interleukin 11
Synonyms AGIF; IL-11
Species Homo sapiens
Ensembl Gene ENSG00000095752
Encoded Proteins
IDBP-70604
interleukin 11
IDBP-765436
IDBP-765642
IDBP-766192
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55364389-55370463
Strand Reverse strand
Band q13.42
Transcripts
ENST00000264563 ENSP00000264563
ENST00000590625 ENSP00000465705
ENST00000587093 ENSP00000468663
ENST00000585513 ENSP00000467355
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 6 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005142 interleukin-11 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0030183 B cell differentiation
GO:0030219 megakaryocyte differentiation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043410 positive regulation of MAPK cascade
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046888 negative regulation of hormone secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004371
View Gene Order
ENSBTAG00000047400
Not yet available
Pathways
NETPATH
NetPath_147
IL11 pathway
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL K7ESD5
UniProt Splice Variant
Entrez Gene 3589
UniGene Hs.467304
RefSeq NM_000641 NM_001267718
HUGO HGNC:5966
OMIM 147681
CCDS CCDS12923 CCDS59423
HPRD 00980
IMGT
EMBL AC020922
GenPept
RNA Seq Atlas 3589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca