InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nlrc3

Summary

InnateDB Protein

IDBP-706921.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nlrc3

Protein Name

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137325

InnateDB Gene

IDBG-129350 (Nlrc3)

Protein Structure

UniProt Annotation

Function

May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0031396	regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032496	response to lipopolysaccharide
GO:0042110	T cell activation
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)