Version 5.4
Homo sapiens Protein: SSC5D
Summary
InnateDB Protein IDBP-70814.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSC5D
Protein Name scavenger receptor cysteine rich domain containing (5 domains)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000374274
InnateDB Gene IDBG-70810 (SSC5D)
Protein Structure
UniProt Annotation
Function Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in monocytes/macrophages and T-lymphocytes. Highly expressed in placenta and spleen, and also detected at lower levels in colon, and more weakly in lung, heart and kidney. {ECO:0000269PubMed:19535143}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0043236 laminin binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0006952 defense response
GO:0007275 multicellular organismal development
GO:0042494 detection of bacterial lipoprotein
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:2000482 regulation of interleukin-8 secretion
GO:2000483 negative regulation of interleukin-8 secretion
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR001190 SRCR domain
IPR017448 SRCR-like domain
PFAM PF00530
PRINTS PR00258
PIRSF
SMART SM00202
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1L4H1
PhosphoSite PhosphoSite-A1L4H1
TrEMBL M0QZ17
UniProt Splice Variant
Entrez Gene 284297
UniGene Hs.554182
RefSeq NP_001138422
HUGO HGNC:26641
OMIM
CCDS CCDS46196
HPRD 11444
IMGT
EMBL AC008735 BC130538 BC130540 EU699476 EU699477
GenPept AAI30539 AAI30541 ACJ02751 ACJ02752

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca