Version 5.4
Mus musculus Protein: Cpsf6
Summary
InnateDB Protein IDBP-710711.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpsf6
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000135136
InnateDB Gene IDBG-191782 (Cpsf6)
Protein Structure
UniProt Annotation
Function Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 56 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003729 mRNA binding
Biological Process
GO:0006378 mRNA polyadenylation
GO:0051262 protein tetramerization
Cellular Component
GO:0005634 nucleus
GO:0005849 mRNA cleavage factor complex
GO:0030529 ribonucleoprotein complex
GO:0042382 paraspeckles
Protein Structure and Domains
PDB ID MGI:1913948
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NVF9
PhosphoSite PhosphoSite-Q6NVF9
TrEMBL
UniProt Splice Variant
Entrez Gene 432508
UniGene Mm.479892
RefSeq XP_006513921
MGI ID
MGI Symbol Cpsf6
OMIM
CCDS CCDS24193
HPRD
IMGT
EMBL AK046856 AK048615 AK168764 BC068133
GenPept AAH68133 BAC32898 BAC33392 BAE40600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca