Homo sapiens Protein: LTK | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Protein | IDBP-7137.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | LTK | ||||||||||||||||||||
Protein Name | leukocyte receptor tyrosine kinase | ||||||||||||||||||||
Synonyms | TYK1; | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Protein | ENSP00000347293 | ||||||||||||||||||||
InnateDB Gene | IDBG-7133 (LTK) | ||||||||||||||||||||
Protein Structure | |||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||
Function | Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. {ECO:0000269PubMed:20548102}. | ||||||||||||||||||||
Subcellular Localization | Membrane; Single-pass type I membrane protein. | ||||||||||||||||||||
Disease Associations | Note=Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to susceptibility to abnormal proliferation of self-reactive B-cells and, therefore, to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to represent a failure of the regulatory mechanisms of the autoimmune system. | ||||||||||||||||||||
Tissue Specificity | Expressed in non-hematopoietic cell lines and T- and B-cell lines. {ECO:0000269PubMed:2156206}. | ||||||||||||||||||||
Comments | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||
PDB ID | |||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||
Modification | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | P29376 | ||||||||||||||||||||
PhosphoSite | PhosphoSite-P29376 | ||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 4058 | ||||||||||||||||||||
UniGene | Hs.434481 | ||||||||||||||||||||
RefSeq | NP_996844 | ||||||||||||||||||||
HUGO | HGNC:6721 | ||||||||||||||||||||
OMIM | 151520 | ||||||||||||||||||||
CCDS | CCDS10078 | ||||||||||||||||||||
HPRD | 01052 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AC016134 AC087721 AK296892 CH471125 D16105 X52213 X60702 | ||||||||||||||||||||
GenPept | BAA03679 BAG59451 CAA36460 CAA43113 EAW92496 | ||||||||||||||||||||