Version 5.4
Homo sapiens Gene: LTK
Summary
InnateDB Gene IDBG-7133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTK
Gene Name leukocyte receptor tyrosine kinase
Synonyms TYK1
Species Homo sapiens
Ensembl Gene ENSG00000062524
Encoded Proteins
IDBP-7137
leukocyte receptor tyrosine kinase
IDBP-7139
leukocyte receptor tyrosine kinase
IDBP-367174
leukocyte receptor tyrosine kinase
IDBP-744999
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:41503638-41513887
Strand Reverse strand
Band q15.1
Transcripts
ENST00000355166 ENSP00000347293
ENST00000263800 ENSP00000263800
ENST00000453182 ENSP00000392196
ENST00000561619 ENSP00000458111
ENST00000563518
ENST00000569283
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008283 cell proliferation
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010976 positive regulation of neuron projection development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000027297
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.434481
RefSeq NM_001135685 NM_002344 NM_206961 XM_005254381 XM_005254382
HUGO
OMIM
CCDS CCDS10077 CCDS10078 CCDS45237
HPRD 01052
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca