InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clec5a

Summary

InnateDB Protein

IDBP-715751.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clec5a

Protein Name

Synonyms

Clecsf5; Ly100; MDL-1; Mdl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135240

InnateDB Gene

IDBG-139294 (Clec5a)

Protein Structure

UniProt Annotation

Function

Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through phosphylation of TYROBP, this interaction does not result in viral entry but stimulates proinflammatory cytokine release. {ECO:0000269PubMed:10449773, ECO:0000269PubMed:18496526, ECO:0000269PubMed:19251634, ECO:0000269PubMed:20212065}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19074552}; Single-pass type II membrane protein {ECO:0000269PubMed:19074552}.

Disease Associations

Note=Involved in the pathogenetic mechanisms of Japanese encephalitis virus (JEV) infection of the brain. JEV infection of young mice results in increased expression of CLEC5A in spleen and brain with consequent activation of proinflammatory cytokines secretion.

Tissue Specificity

Expressed in macrophage cell line J-774, but not in T-cell lines, B-cell lines, or mast cell lines. Strong expression in bone marrow cells or thioglycollate induced neutrophils (at protein level). {ECO:0000269PubMed:10449773, ECO:0000269PubMed:19074552, ECO:0000269PubMed:20212065}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0002076	osteoblast development
GO:0009615	response to virus
GO:0033033	negative regulation of myeloid cell apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response
GO:0050715	positive regulation of cytokine secretion