Mus musculus Gene: Clec5a
Summary
InnateDB Gene IDBG-139294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clec5a
Gene Name C-type lectin domain family 5, member a
Synonyms Clecsf5; Ly100; MDL-1; Mdl1;
Species Mus musculus
Ensembl Gene ENSMUSG00000029915
Encoded Proteins
C-type lectin domain family 5, member a
C-type lectin domain family 5, member a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000258227:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:40574894-40585821
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000031975
ENSMUST00000101491 ENSMUSP00000099030
ENSMUST00000129948 ENSMUSP00000121848
ENSMUST00000177178 ENSMUSP00000135240
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0002076 osteoblast development
GO:0009615 response to virus
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Immune System pathway
DAP12 interactions pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Innate Immune System pathway
Immune System pathway
DAP12 interactions pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9R007
TrEMBL
UniProt Splice Variant
Entrez Gene 23845
UniGene Mm.103765
RefSeq NM_021364 NM_001038604
OMIM
CCDS CCDS20037 CCDS20036
HPRD
IMGT
MGI ID MGI:1345151
MGI Symbol Clec5a
EMBL AF139769 AK036697 AK046600 AK137482 BC104364 BC104365 CH466533
GenPept AAF02492 AAI04365 AAI04366 BAC29537 BAC32802 BAE23374 EDL13570
RNA Seq Atlas 23845