InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sept2

Summary

InnateDB Protein

IDBP-716679.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sept2

Protein Name

Synonyms

AW208991; mKIAA0158; Nedd-5; Nedd5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136366

InnateDB Gene

IDBG-183376 (Sept2)

Protein Structure

UniProt Annotation

Function

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements (By similarity). In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. {ECO:0000250, ECO:0000269PubMed:20558667, ECO:0000269PubMed:22179047, ECO:0000269PubMed:9203580}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, cilium membrane. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle (By similarity). In interphase and postmitotic cells, localised to fibrous or granular structures, depending on the growth state of the cell. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0030234	enzyme regulator activity
GO:0032947	protein complex scaffold
GO:0042802	identical protein binding

Biological Process

GO:0000910	cytokinesis
GO:0002036	regulation of L-glutamate transport
GO:0006184	GTP catabolic process
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0007224	smoothened signaling pathway
GO:0031175	neuron projection development
GO:0032880	regulation of protein localization
GO:0042384	cilium assembly
GO:0050790	regulation of catalytic activity
GO:0051258	protein polymerization

Cellular Component

GO:0000145	exocyst
GO:0000777	condensed chromosome kinetochore
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005826	actomyosin contractile ring
GO:0005876	spindle microtubule
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0009986	cell surface
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0030496	midbody
GO:0031105	septin complex
GO:0032154	cleavage furrow
GO:0035869	ciliary transition zone
GO:0042995	cell projection
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0060170	ciliary membrane