InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmox1

Summary

InnateDB Protein

IDBP-717700.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmox1

Protein Name

Synonyms

D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135466

InnateDB Gene

IDBG-168890 (Hmox1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004392	heme oxygenase (decyclizing) activity
GO:0004630	phospholipase D activity
GO:0004871	signal transducer activity
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0002246	wound healing involved in inflammatory response
GO:0006788	heme oxidation
GO:0007264	small GTPase mediated signal transduction
GO:0008217	regulation of blood pressure
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0031670	cellular response to nutrient
GO:0032764	negative regulation of mast cell cytokine production
GO:0034101	erythrocyte homeostasis
GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
GO:0035094	response to nicotine
GO:0042167	heme catabolic process
GO:0042168	heme metabolic process
GO:0042542	response to hydrogen peroxide
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043305	negative regulation of mast cell degranulation
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043627	response to estrogen
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051260	protein homooligomerization
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0071243	cellular response to arsenic-containing substance
GO:0071276	cellular response to cadmium ion
GO:0071456	cellular response to hypoxia
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005730	nucleolus
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005901	caveola

Protein Structure and Domains

PDB ID

MGI:96163

InterPro

IPR002051 Haem oxygenase
IPR016053 Haem oxygenase-like
IPR016084 Haem oxygenase-like, multi-helical

PFAM

PF01126

PRINTS

PR00088

PIRSF

PIRSF000343

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

H3BKP1

UniProt Splice Variant

Entrez Gene

15368

UniGene

Mm.276389

RefSeq

MGI ID

MGI Symbol

Hmox1

OMIM

CCDS

HPRD

IMGT

EMBL

AC084823

GenPept