InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nrg3

Summary

InnateDB Protein

IDBP-718007.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrg3

Protein Name

Synonyms

ska;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136884

InnateDB Gene

IDBG-151248 (Nrg3)

Protein Structure

UniProt Annotation

Function

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. {ECO:0000269PubMed:9275162}.

Subcellular Localization

Pro-neuregulin-3, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.Neuregulin-3: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in sympathetic, motor, and sensory neurons.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0007389	pattern specification process
GO:0030879	mammary gland development
GO:0035556	intracellular signal transduction
GO:0060596	mammary placode formation