InnateDB Protein
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IDBP-718020.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slu7
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Protein Name
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000137281
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InnateDB Gene
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IDBG-164064 (Slu7)
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Protein Structure
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Function |
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
19 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2385598
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InterPro |
IPR001878
Zinc finger, CCHC-type
IPR021715
Pre-mRNA splicing Prp18-interacting factor
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PFAM |
PF00098
PF11708
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PRINTS |
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PIRSF |
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SMART |
SM00343
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BHJ9
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PhosphoSite |
PhosphoSite-Q8BHJ9
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TrEMBL |
Z4YM25
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UniProt Splice Variant |
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Entrez Gene |
193116
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UniGene |
Mm.28200
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RefSeq |
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MGI ID |
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MGI Symbol |
Slu7
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OMIM |
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CCDS |
CCDS24557
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HPRD |
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IMGT |
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EMBL |
AK029117
AK046262
AK047597
AK049178
AL670472
BC013810
BC023057
BC060954
BC082780
BC106099
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GenPept |
AAH13810
AAH23057
AAH60954
AAH82780
AAI06100
BAC26306
BAC32662
BAC33093
BAC33589
CAI24830
CAI24831
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