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InnateDB Protein
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IDBP-718067.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Disc1
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Protein Name
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000111552
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InnateDB Gene
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IDBG-200561 (Disc1)
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Protein Structure
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| Function |
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. {ECO:0000269PubMed:17825401, ECO:0000269PubMed:19303846, ECO:0000269PubMed:19502360, ECO:0000269PubMed:19778506}.
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| Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with PCNT at the centrosome. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Expressed in granule cell precursors within the dentate migratory stream during the first week of postnatal life and in differentiated granule cells of the hippocampus (at protein level). Expressed in dentate gyrus, hippocampus and in the olfactory bulb. {ECO:0000269PubMed:17825401, ECO:0000269PubMed:19502360}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
10
[view]
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| Protein-Protein |
10
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
115 [view]
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| PDB ID |
MGI:2447658
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| InterPro |
IPR009053
Prefoldin
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q811T9
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| TrEMBL |
Z4YLG9
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| UniProt Splice Variant |
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| Entrez Gene |
244667
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| UniGene |
Mm.233504
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Disc1
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL672234
AL731650
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| GenPept |
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Version 5.4