InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp8ap2

Summary

InnateDB Protein

IDBP-718914.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp8ap2

Protein Name

Synonyms

AA387232; D4Ertd659e; FLASH; mKIAA1315;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136016

InnateDB Gene

IDBG-133238 (Casp8ap2)

Protein Structure

UniProt Annotation

Function

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (By similarity). Required for histone gene transcription and progression through S phase (By similarity). Required for histone gene transcription and S phase progression (By similarity). Involved in TNF-alpha-induced activation of NF- kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. {ECO:0000250, ECO:0000269PubMed:11340079, ECO:0000269PubMed:15592525}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269PubMed:17003125}. Nucleus, PML body {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Exported from the nucleus to the mitochondria upon FAS activation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart, brain, thymus, lung, testis and spleen. {ECO:0000269PubMed:10235259}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0032184	SUMO polymer binding
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049	cell cycle
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0036337	Fas signaling pathway