InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYLK

Summary

InnateDB Protein

IDBP-719604.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYLK

Protein Name

Synonyms

AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK1; smMLCK;

Species

Homo sapiens

Ensembl Protein

ENSP00000463691

InnateDB Gene

IDBG-53043 (MYLK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004687	myosin light chain kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006936	muscle contraction
GO:0006939	smooth muscle contraction
GO:0007015	actin filament organization
GO:0014820	tonic smooth muscle contraction
GO:0030335	positive regulation of cell migration
GO:0032060	bleb assembly
GO:0051928	positive regulation of calcium ion transport
GO:0060414	aorta smooth muscle tissue morphogenesis
GO:0071476	cellular hypotonic response
GO:0090303	positive regulation of wound healing

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030027	lamellipodium
GO:0032154	cleavage furrow
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF07679
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15746