InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYLK

Summary

InnateDB Gene

IDBG-53043.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYLK

Gene Name

myosin light chain kinase

Synonyms

AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK1; smMLCK

Species

Homo sapiens

Ensembl Gene

ENSG00000065534

Encoded Proteins

IDBP-53045

myosin light chain kinase

IDBP-53047

myosin light chain kinase

IDBP-53049

myosin light chain kinase

IDBP-53051

myosin light chain kinase

IDBP-53057

myosin light chain kinase

IDBP-476347

myosin light chain kinase

IDBP-477841

myosin light chain kinase

IDBP-483338

myosin light chain kinase

IDBP-477340

myosin light chain kinase

IDBP-719604

IDBP-719769

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3\' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:123610049-123884331

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000360304	ENSP00000353452
ENST00000360772	ENSP00000354004
ENST00000359169	ENSP00000352088
ENST00000346322	ENSP00000320622
ENST00000354792	ENSP00000346846
ENST00000418370	ENSP00000428967
ENST00000464489	ENSP00000417798
ENST00000475616	ENSP00000418335
ENST00000515434
ENST00000514895
ENST00000513111
ENST00000508240	ENSP00000422984
ENST00000510775
ENST00000511058
ENST00000504946
ENST00000503644
ENST00000514623
ENST00000506361
ENST00000510571
ENST00000578202	ENSP00000463691
ENST00000583087	ENSP00000462118

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004687	myosin light chain kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006936	muscle contraction
GO:0006939	smooth muscle contraction
GO:0007015	actin filament organization
GO:0014820	tonic smooth muscle contraction
GO:0030335	positive regulation of cell migration
GO:0032060	bleb assembly
GO:0051928	positive regulation of calcium ion transport
GO:0060414	aorta smooth muscle tissue morphogenesis
GO:0071476	cellular hypotonic response
GO:0090303	positive regulation of wound healing

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0030027	lamellipodium
GO:0032154	cleavage furrow
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022836

View Gene Order

ENSBTAG00000014567

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

REACT_20558

Smooth Muscle Contraction pathway

REACT_17044

Muscle contraction pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04510

Focal adhesion pathway

hsa04020

Calcium signaling pathway pathway

hsa04270

Vascular smooth muscle contraction pathway

hsa04971

Gastric acid secretion pathway

INOH

PID NCI

aurora_b_pathway

Aurora B signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.477375 Hs.594108 Hs.600605 Hs.625965 Hs.638679

RefSeq

NM_053025 NM_053026 NM_053027 NM_053028 NM_053031 NM_053032 XM_005247492 XM_005247494 XM_006713649

HUGO

OMIM

CCDS

CCDS3023 CCDS43141 CCDS46896 CCDS46897 CCDS58849

HPRD

02952

IMGT

EMBL

GenPept

RNA Seq Atlas