Homo sapiens Gene: MYLK
Summary
InnateDB Gene IDBG-53043.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYLK
Gene Name myosin light chain kinase
Synonyms AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK1; smMLCK;
Species Homo sapiens
Ensembl Gene ENSG00000065534
Encoded Proteins
myosin light chain kinase
myosin light chain kinase
myosin light chain kinase
myosin light chain kinase
myosin light chain kinase
myosin light chain kinase
myosin light chain kinase
myosin light chain kinase
myosin light chain kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3\' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:123610049-123884331
Strand Reverse strand
Band q21.1
Transcripts
ENST00000360304 ENSP00000353452
ENST00000360772 ENSP00000354004
ENST00000359169 ENSP00000352088
ENST00000346322 ENSP00000320622
ENST00000354792 ENSP00000346846
ENST00000418370 ENSP00000428967
ENST00000464489 ENSP00000417798
ENST00000475616 ENSP00000418335
ENST00000515434
ENST00000514895
ENST00000513111
ENST00000508240 ENSP00000422984
ENST00000510775
ENST00000511058
ENST00000504946
ENST00000503644
ENST00000514623
ENST00000506361
ENST00000510571
ENST00000578202 ENSP00000463691
ENST00000583087 ENSP00000462118
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004687 myosin light chain kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006936 muscle contraction
GO:0006939 smooth muscle contraction
GO:0007015 actin filament organization
GO:0014820 tonic smooth muscle contraction
GO:0030335 positive regulation of cell migration
GO:0032060 bleb assembly
GO:0051928 positive regulation of calcium ion transport
GO:0060414 aorta smooth muscle tissue morphogenesis
GO:0071476 cellular hypotonic response
GO:0090303 positive regulation of wound healing
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0030027 lamellipodium
GO:0032154 cleavage furrow
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TNFalpha pathway
REACTOME
Smooth Muscle Contraction pathway
Muscle contraction pathway
KEGG
Calcium signaling pathway pathway
Vascular smooth muscle contraction pathway
Focal adhesion pathway
Regulation of actin cytoskeleton pathway
Gastric acid secretion pathway
INOH
PID BIOCARTA
Rho cell motility signaling pathway [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Biocarta view]
PID NCI
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.477375 Hs.594108 Hs.600605 Hs.625965 Hs.638679
RefSeq NM_053025 NM_053026 NM_053027 NM_053028 NM_053031 NM_053032 XM_005247492 XM_005247494 XM_006713649
HUGO
OMIM
CCDS CCDS3023 CCDS43141 CCDS46896 CCDS46897 CCDS58849
HPRD 02952
IMGT
EMBL
GenPept
RNA Seq Atlas