InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LGALS3

Summary

InnateDB Protein

IDBP-7249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGALS3

Protein Name

lectin, galactoside-binding, soluble, 3

Synonyms

CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000254301

InnateDB Gene

IDBG-7247 (LGALS3)

Protein Structure

UniProt Annotation

Function

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. {ECO:0000250, ECO:0000269PubMed:15181153, ECO:0000269PubMed:19594635, ECO:0000269PubMed:19616076}.

Subcellular Localization

Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface.

Disease Associations

Tissue Specificity

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. {ECO:0000269PubMed:19497882}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	71 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019863	IgE binding
GO:0030246	carbohydrate binding
GO:0042056	chemoattractant activity
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001501	skeletal system development
GO:0002548	monocyte chemotaxis
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0030855	epithelial cell differentiation
GO:0042129	regulation of T cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045806	negative regulation of endocytosis
GO:0048245	eosinophil chemotaxis
GO:0048246	macrophage chemotaxis
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050918	positive chemotaxis
GO:0070232	regulation of T cell apoptotic process
GO:0071674	mononuclear cell migration
GO:0071677	positive regulation of mononuclear cell migration
GO:0090280	positive regulation of calcium ion import
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000521	negative regulation of immunological synapse formation
GO:2001189	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome