Homo sapiens Gene: LGALS3
Summary
InnateDB Gene IDBG-7247.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS3
Gene Name lectin, galactoside-binding, soluble, 3
Synonyms CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2;
Species Homo sapiens
Ensembl Gene ENSG00000131981
Encoded Proteins
lectin, galactoside-binding, soluble, 3
lectin, galactoside-binding, soluble, 3
lectin, galactoside-binding, soluble, 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
LGALS3 exerts a regulatory role in innate immunity by diminishing IL-1beta production and thus affecting resistance to Rhodococcus equi infection.
LGALS3, an abundant protein in macrophages and epithelial cells, belongs to a family of beta-galactoside-binding proteins, the galectins, with many proposed functions in immune response, development, differentiation, cancer and infection.
LGALS3 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.
LGALS3 influences the course of malaria in a Plasmodium species-specific manner. (Demonstrated in mice)
LGALS1 and LGALS3 play opposing roles in the inflammatory responses to Trichomonas vaginalis infection.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Lgals3 influences the course of malaria in a Plasmodium species-specific manner.
[Mus musculus] Lgals3 plays an important role in innate immunity to infection and colonization of Helicobacter pylori.
Entrez Gene
Summary This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:55124110-55145413
Strand Forward strand
Band q22.3
Transcripts
ENST00000254301 ENSP00000254301
ENST00000553493 ENSP00000451526
ENST00000553755
ENST00000554715 ENSP00000451381
ENST00000556438
ENST00000556322
ENST00000556263
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 76 [view]
Protein-Protein 71 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019863 IgE binding
GO:0030246 carbohydrate binding
GO:0042056 chemoattractant activity
GO:0043236 laminin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001501 skeletal system development
GO:0002548 monocyte chemotaxis
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0030198 extracellular matrix organization
GO:0030593 neutrophil chemotaxis
GO:0030855 epithelial cell differentiation
GO:0042129 regulation of T cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0045806 negative regulation of endocytosis
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050918 positive chemotaxis
GO:0070232 regulation of T cell apoptotic process
GO:0071674 mononuclear cell migration
GO:0071677 positive regulation of mononuclear cell migration
GO:0090280 positive regulation of calcium ion import
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000521 negative regulation of immunological synapse formation
GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Immune System pathway
Advanced glycosylation endproduct receptor signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of Ras family activation
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.531081 Hs.619784 Hs.734248
RefSeq NM_002306
HUGO
OMIM
CCDS CCDS41956
HPRD 17026
IMGT
EMBL
GenPept
RNA Seq Atlas