InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOCS6

Summary

InnateDB Protein

IDBP-725877.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOCS6

Protein Name

Synonyms

CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6; SOCS4; SSI4; STAI4; STATI4;

Species

Homo sapiens

Ensembl Protein

ENSP00000463395

InnateDB Gene

IDBG-4847 (SOCS6)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269PubMed:21030588}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006952	defense response
GO:0007259	JAK-STAT cascade
GO:0009968	negative regulation of signal transduction
GO:0010498	proteasomal protein catabolic process
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)