Version 5.4
Homo sapiens Gene: SOCS6
Summary
InnateDB Gene IDBG-4847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS6
Gene Name suppressor of cytokine signaling 6
Synonyms CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6; SOCS4; SSI4; STAI4; STATI4
Species Homo sapiens
Ensembl Gene ENSG00000170677
Encoded Proteins
IDBP-234244
suppressor of cytokine signaling 6
IDBP-725569
IDBP-725877
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 14707129
SOCS6 associates with KIT and regulates KIT receptor signalling and leads to MAPK activation.
Entrez Gene
Summary The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:70288901-70330200
Strand Forward strand
Band q22.2
Transcripts
ENST00000397942 ENSP00000381034
ENST00000578377 ENSP00000463064
ENST00000582322 ENSP00000463395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0007259 JAK-STAT cascade
GO:0009968 negative regulation of signal transduction
GO:0010498 proteasomal protein catabolic process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0045087 innate immune response (InnateDB)
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0001772 immunological synapse
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056153
View Gene Order
ENSBTAG00000017412
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.44439 Hs.603129 Hs.623364
RefSeq NM_004232 XM_005266783 XM_006722577
HUGO
OMIM
CCDS CCDS11998
HPRD 05491
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca