|Homo sapiens Gene: SOCS6|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||suppressor of cytokine signaling 6|
|Synonyms||CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6; SOCS4; SSI4; STAI4; STATI4;|
suppressor of cytokine signaling 6
|Useful resources||Stemformatics EHFPI ImmGen|
SOCS6 associates with KIT and regulates KIT receptor signalling and leads to MAPK activation.
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 18:70288901-70330200|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Possible paralog/unusual divergence/ gene prediction error
Signaling by SCF-KIT pathway
Signal Transduction pathway
Regulation of KIT signaling pathway
JAK STAT pathway and regulation pathway
|UniProt Splice Variant|
|UniGene||Hs.44439 Hs.603129 Hs.623364|
|RefSeq||NM_004232 XM_005266783 XM_006722577|
|EMBL||AB006968 AC023395 BC020082 CH471117|
|GenPept||AAH20082 BAA22538 EAW66522 EAW66523|
|RNA Seq Atlas||9306|