Homo sapiens Gene: SOCS6
Summary
InnateDB Gene IDBG-4847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS6
Gene Name suppressor of cytokine signaling 6
Synonyms CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6; SOCS4; SSI4; STAI4; STATI4;
Species Homo sapiens
Ensembl Gene ENSG00000170677
Encoded Proteins
suppressor of cytokine signaling 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
SOCS6 associates with KIT and regulates KIT receptor signalling and leads to MAPK activation.
Entrez Gene
Summary The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:70288901-70330200
Strand Forward strand
Band q22.2
Transcripts
ENST00000397942 ENSP00000381034
ENST00000578377 ENSP00000463064
ENST00000582322 ENSP00000463395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0007259 JAK-STAT cascade
GO:0009968 negative regulation of signal transduction
GO:0010498 proteasomal protein catabolic process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0045087 innate immune response (InnateDB)
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0001772 immunological synapse
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
KitReceptor pathway
REACTOME
Signaling by SCF-KIT pathway
Signal Transduction pathway
Regulation of KIT signaling pathway
KEGG
INOH
JAK STAT pathway and regulation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O14544
TrEMBL A0A024R379 J3KTM7
UniProt Splice Variant
Entrez Gene 9306
UniGene Hs.44439 Hs.603129 Hs.623364
RefSeq NM_004232 XM_005266783 XM_006722577
HUGO HGNC:16833
OMIM 605118
CCDS CCDS11998
HPRD
IMGT
EMBL AB006968 AC023395 BC020082 CH471117
GenPept AAH20082 BAA22538 EAW66522 EAW66523
RNA Seq Atlas 9306