InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFATC1

Summary

InnateDB Protein

IDBP-726158.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFATC1

Protein Name

Synonyms

NF-ATC; NFAT2; NFATc;

Species

Homo sapiens

Ensembl Protein

ENSP00000466489

InnateDB Gene

IDBG-5452 (NFATC1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	41 [view]
Protein-DNA	20 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001085	RNA polymerase II transcription factor binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0044212	transcription regulatory region DNA binding
GO:0048273	mitogen-activated protein kinase p38 binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002909 IPT domain
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set

PFAM

PF01833
PF00554

PRINTS

PR01789

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt