InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB31

Summary

InnateDB Protein

IDBP-726275.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB31

Protein Name

Synonyms

Rab22B;

Species

Homo sapiens

Ensembl Protein

ENSP00000461945

InnateDB Gene

IDBG-822 (RAB31)

Protein Structure

UniProt Annotation

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269PubMed:17189207, ECO:0000269PubMed:17678623, ECO:0000269PubMed:19725050, ECO:0000269PubMed:21255211, ECO:0000269PubMed:21586568}.

Subcellular Localization

Golgi apparatus, trans-Golgi network. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid- anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis.

Disease Associations

Tissue Specificity

Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas. {ECO:0000269PubMed:11784320}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0031623	receptor internalization
GO:0032869	cellular response to insulin stimulus
GO:0043001	Golgi to plasma membrane protein transport
GO:0045055	regulated secretory pathway
GO:0048193	Golgi vesicle transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0045335	phagocytic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670
PF08477

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt