InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN2

Summary

InnateDB Protein

IDBP-726451.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN2

Protein Name

Synonyms

PTN2; PTPT; TC-PTP; TCELLPTP; TCPTP;

Species

Homo sapiens

Ensembl Protein

ENSP00000466936

InnateDB Gene

IDBG-1165 (PTPN2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0019905	syntaxin binding
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888	negative regulation of lipid storage
GO:0016311	dephosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030218	erythrocyte differentiation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042512	negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042527	negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0042593	glucose homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0045650	negative regulation of macrophage differentiation
GO:0045722	positive regulation of gluconeogenesis
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050728	negative regulation of inflammatory response
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050922	negative regulation of chemotaxis
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339	negative regulation of type I interferon-mediated signaling pathway
GO:0070104	negative regulation of interleukin-6-mediated signaling pathway
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206	negative regulation of interleukin-2-mediated signaling pathway
GO:1902212	negative regulation of prolactin signaling pathway
GO:1902215	negative regulation of interleukin-4-mediated signaling pathway
GO:1902227	negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233	negative regulation of positive thymic T cell selection
GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005783	endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700

PIRSF

PIRSF000926

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References