Version 5.4
Homo sapiens Gene: PTPN2
Summary
InnateDB Gene IDBG-1165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN2
Gene Name protein tyrosine phosphatase, non-receptor type 2
Synonyms PTN2; PTPT; TC-PTP; TCELLPTP; TCPTP
Species Homo sapiens
Ensembl Gene ENSG00000175354
Encoded Proteins
IDBP-1167
protein tyrosine phosphatase, non-receptor type 2
IDBP-1169
protein tyrosine phosphatase, non-receptor type 2
IDBP-1173
protein tyrosine phosphatase, non-receptor type 2
IDBP-726734
IDBP-726451
IDBP-725700
IDBP-727605
IDBP-728031
IDBP-725778
IDBP-726024
IDBP-725883
IDBP-727305
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 14600148
PTPN2 pays a novel role in the regulation of type 1 interferon-stimulated gene expression in cells previously desensitized to Type 1 interferons.
PMID 11773439
PTPN2 is a nuclear protein tyrosine phosphatase, a potential negative regulator of the PRL-mediated signalling pathway.
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:12785478-12929643
Strand Reverse strand
Band p11.21
Transcripts
ENST00000327283 ENSP00000320298
ENST00000353319 ENSP00000320546
ENST00000309660 ENSP00000311857
ENST00000592059 ENSP00000466206
ENST00000591115 ENSP00000466936
ENST00000589216 ENSP00000468408
ENST00000591901 ENSP00000464937
ENST00000591305 ENSP00000468012
ENST00000591497 ENSP00000467823
ENST00000585666 ENSP00000464719
ENST00000589086
ENST00000587703 ENSP00000467043
ENST00000587497
ENST00000589444
ENST00000592776 ENSP00000468155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888 negative regulation of lipid storage
GO:0016311 dephosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042512 negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042527 negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0042593 glucose homeostasis
GO:0045087 innate immune response (InnateDB)
GO:0045650 negative regulation of macrophage differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050922 negative regulation of chemotaxis
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206 negative regulation of interleukin-2-mediated signaling pathway
GO:1902212 negative regulation of prolactin signaling pathway
GO:1902215 negative regulation of interleukin-4-mediated signaling pathway
GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233 negative regulation of positive thymic T cell selection
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024539
View Gene Order
ENSBTAG00000010563
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
tcptp_pathway
Signaling events mediated by TCPTP
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
pdgfrbpathway
PDGFR-beta signaling pathway
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654527
RefSeq NM_001207013 NM_002828 NM_080422 NM_080423 XM_005258127
HUGO
OMIM
CCDS CCDS11863 CCDS11864 CCDS11865 CCDS59306
HPRD 06768
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca