Homo sapiens Protein: TRIM28 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-73195.7 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | TRIM28 | ||||||||||||||||||||||||||
Protein Name | tripartite motif containing 28 | ||||||||||||||||||||||||||
Synonyms | KAP1; PPP1R157; RNF96; TF1B; TIF1B; | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Protein | ENSP00000342232 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-73191 (TRIM28) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. {ECO:0000269PubMed:10347202, ECO:0000269PubMed:11959841, ECO:0000269PubMed:15882967, ECO:0000269PubMed:16107876, ECO:0000269PubMed:16862143, ECO:0000269PubMed:17079232, ECO:0000269PubMed:17178852, ECO:0000269PubMed:17704056, ECO:0000269PubMed:17942393, ECO:0000269PubMed:18060868, ECO:0000269PubMed:18082607, ECO:0000269PubMed:20424263, ECO:0000269PubMed:20858735, ECO:0000269PubMed:20864041, ECO:0000269PubMed:21940674, ECO:0000269PubMed:23665872, ECO:0000269PubMed:8769649, ECO:0000269PubMed:9016654}. | ||||||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000269PubMed:10330177, ECO:0000269PubMed:17178852, ECO:0000269PubMed:20858735, ECO:0000269PubMed:23665872, ECO:0000269PubMed:9016654}. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1. {ECO:0000250}. | ||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||
Tissue Specificity | Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269PubMed:9016654}. | ||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 271 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR000315
Zinc finger, B-box IPR001487 Bromodomain IPR001841 Zinc finger, RING-type IPR001965 Zinc finger, PHD-type IPR003649 B-box, C-terminal IPR011011 Zinc finger, FYVE/PHD-type IPR019787 Zinc finger, PHD-finger |
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PFAM |
PF00643
PF00439 PF13639 PF14634 PF00628 |
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PRINTS |
PR00503
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PIRSF | |||||||||||||||||||||||||||
SMART |
SM00336
SM00297 SM00184 SM00249 SM00502 |
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TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | Q13263 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q13263 | ||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 10155 | ||||||||||||||||||||||||||
UniGene | Hs.467408 | ||||||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||||||
HUGO | HGNC:16384 | ||||||||||||||||||||||||||
OMIM | 601742 | ||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | 03445 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | BC004978 BC007390 BC052986 U31657 U78773 U95040 X97548 | ||||||||||||||||||||||||||
GenPept | AAA74954 AAB37341 AAB51517 AAH04978 AAH07390 AAH52986 CAA66150 | ||||||||||||||||||||||||||