Version 5.4
Homo sapiens Protein: MARCH7
Summary
InnateDB Protein IDBP-73261.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH7
Protein Name membrane-associated ring finger (C3HC4) 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000259050
InnateDB Gene IDBG-73259 (MARCH7)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269PubMed:16868077}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR011016 Zinc finger, RING-CH-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF12906
PF00097
PRINTS
PIRSF
SMART SM00744
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H992
PhosphoSite PhosphoSite-Q9H992
TrEMBL C9J159
UniProt Splice Variant
Entrez Gene 64844
UniGene
RefSeq NP_073737
HUGO HGNC:17393
OMIM 613334
CCDS CCDS2210
HPRD 09817
IMGT
EMBL AC009961 AK022973 AK222880 AK292836 AK302347 BC003404 BC065014 CH471058
GenPept AAH03404 AAH65014 AAY14941 BAB14340 BAD96600 BAF85525 BAH13681 EAX11402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca