InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G6

Summary

InnateDB Protein

IDBP-7327.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G6

Protein Name

phospholipase A2, group VI (cytosolic, calcium-independent)

Synonyms

CaI-PLA2; GVI; INAD1; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PNPLA9;

Species

Homo sapiens

Ensembl Protein

ENSP00000333142

InnateDB Gene

IDBG-7325 (PLA2G6)

Protein Structure

UniProt Annotation

Function

Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods.Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.

Subcellular Localization

Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.Isoform SH-iPLA2: Cytoplasm.

Disease Associations

Neurodegeneration with brain iron accumulation 2B (NBIA2B) [MIM:610217]: A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by progressive extrapyramidal dysfunction leading to rigidity, dystonia, dysarthria and sensorimotor impairment. {ECO:0000269PubMed:16783378}. Note=The disease is caused by mutations affecting the gene represented in this entry.Neurodegeneration with brain iron accumulation 2A (NBIA2A) [MIM:256600]: A neurodegenerative disease characterized by pathologic axonal swelling and spheroid bodies in the central nervous system. Onset is within the first 2 years of life with death by age 10 years. {ECO:0000269PubMed:16783378, ECO:0000269PubMed:17033970, ECO:0000269PubMed:23749988}. Note=The disease is caused by mutations affecting the gene represented in this entry.Parkinson disease 14 (PARK14) [MIM:612953]: An adult- onset progressive neurodegenerative disorder characterized by parkinsonism, dystonia, severe cognitive decline, cerebral and cerebellar atrophy and absent iron in the basal ganglia on magnetic resonance imaging. {ECO:0000269PubMed:18570303}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Four different transcripts were found to be expressed in a distinct tissue distribution.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	5 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004623	phospholipase A2 activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0043008	ATP-dependent protein binding
GO:0047499	calcium-independent phospholipase A2 activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006935	chemotaxis
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007613	memory
GO:0008152	metabolic process
GO:0008219	cell death
GO:0014832	urinary bladder smooth muscle contraction
GO:0016042	lipid catabolic process
GO:0032049	cardiolipin biosynthetic process
GO:0034976	response to endoplasmic reticulum stress
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035965	cardiolipin acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0045909	positive regulation of vasodilation
GO:0045921	positive regulation of exocytosis
GO:0046474	glycerophospholipid biosynthetic process
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060135	maternal process involved in female pregnancy
GO:0090037	positive regulation of protein kinase C signaling
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0090238	positive regulation of arachidonic acid secretion
GO:1901339	regulation of store-operated calcium channel activity
GO:2000304	positive regulation of ceramide biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR002641 Patatin/Phospholipase A2-related
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF01734
PF11929
PF12796

PRINTS

PR01415

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt