Version 5.4
Homo sapiens Gene: PLA2G6
Summary
InnateDB Gene IDBG-7325.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G6
Gene Name phospholipase A2, group VI (cytosolic, calcium-independent)
Synonyms CaI-PLA2; GVI; INAD1; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PNPLA9
Species Homo sapiens
Ensembl Gene ENSG00000184381
Encoded Proteins
IDBP-7327
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-7331
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-293649
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376408
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376411
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376416
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376424
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376427
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376431
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376433
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376437
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376442
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376444
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376446
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376449
phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-719834
IDBP-719840
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:38111495-38205690
Strand Reverse strand
Band q13.1
Transcripts
ENST00000332509 ENSP00000333142
ENST00000335539 ENSP00000335149
ENST00000402064 ENSP00000386100
ENST00000454670 ENSP00000413145
ENST00000448094 ENSP00000407106
ENST00000452794 ENSP00000392968
ENST00000427114 ENSP00000407743
ENST00000427453 ENSP00000408298
ENST00000452542 ENSP00000412629
ENST00000430886 ENSP00000395464
ENST00000436218 ENSP00000401242
ENST00000445591
ENST00000452972
ENST00000447598 ENSP00000393361
ENST00000435484 ENSP00000413597
ENST00000417303 ENSP00000404974
ENST00000455341 ENSP00000393761
ENST00000420435
ENST00000426674
ENST00000463287
ENST00000496409
ENST00000491986
ENST00000490473
ENST00000471636
ENST00000480154
ENST00000498338 ENSP00000472058
ENST00000479641
ENST00000594306 ENSP00000473160
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 5 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0043008 ATP-dependent protein binding
GO:0047499 calcium-independent phospholipase A2 activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006935 chemotaxis
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007613 memory
GO:0008152 metabolic process
GO:0008219 cell death
GO:0014832 urinary bladder smooth muscle contraction
GO:0016042 lipid catabolic process
GO:0032049 cardiolipin biosynthetic process
GO:0034976 response to endoplasmic reticulum stress
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035965 cardiolipin acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0045909 positive regulation of vasodilation
GO:0045921 positive regulation of exocytosis
GO:0046474 glycerophospholipid biosynthetic process
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060135 maternal process involved in female pregnancy
GO:0090037 positive regulation of protein kinase C signaling
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090238 positive regulation of arachidonic acid secretion
GO:1901339 regulation of store-operated calcium channel activity
GO:2000304 positive regulation of ceramide biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042632
View Gene Order
ENSBTAG00000014015
Not yet available
Pathways
NETPATH
REACTOME
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_120829
Acyl chain remodelling of PC pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_121006
Acyl chain remodeling of CL pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_6900
Immune System pathway
REACT_120870
Phospholipid metabolism pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_111217
Metabolism pathway
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa00590
Arachidonic acid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.170479 Hs.641914
RefSeq NM_001004426 NM_001199562 NM_003560 XM_005261764 XM_005261765 XM_005261766 XM_006724332
HUGO
OMIM
CCDS CCDS13967 CCDS33645
HPRD 04675
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca