Version 5.4
Homo sapiens Protein: DSN1
Summary
InnateDB Protein IDBP-73416.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSN1
Protein Name DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362839
InnateDB Gene IDBG-73404 (DSN1)
Protein Structure
UniProt Annotation
Function Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269PubMed:15502821, ECO:0000269PubMed:16585270}.
Subcellular Localization Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 36 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0051301 cell division
Cellular Component
GO:0000444 MIS12/MIND type complex
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR013218 Kinetochore-associated protein Dsn1/Mis13
PFAM PF08202
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H410
PhosphoSite PhosphoSite-Q9H410
TrEMBL
UniProt Splice Variant
Entrez Gene 79980
UniGene Hs.632268
RefSeq NP_001138789
HUGO HGNC:16165
OMIM 609175
CCDS CCDS46596
HPRD 16455
IMGT
EMBL AK023408 AK093031 AK301671 AK301840 AL132768 BC058899 CH471077
GenPept AAH58899 BAB14564 BAC04024 BAG63144 BAG63283 CAC10099 CAI21468 EAW76101 EAW76102 EAW76104 EAW76106

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca