InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL10RA

Summary

InnateDB Protein

IDBP-73421.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL10RA

Protein Name

interleukin 10 receptor, alpha

Synonyms

CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R;

Species

Homo sapiens

Ensembl Protein

ENSP00000227752

InnateDB Gene

IDBG-73419 (IL10RA)

Protein Structure

UniProt Annotation

Function

Receptor for IL10; binds IL10 with a high affinity.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Inflammatory bowel disease 28 (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269PubMed:19890111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004872	receptor activity
GO:0004920	interleukin-10 receptor activity
GO:0005515	protein binding
GO:0019969	interleukin-10 binding