InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2M

Summary

InnateDB Protein

IDBP-73509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2M

Protein Name

ubiquitin-conjugating enzyme E2M

Synonyms

hUbc12; UBC-RS2; UBC12;

Species

Homo sapiens

Ensembl Protein

ENSP00000253023

InnateDB Gene

IDBG-73507 (UBE2M)

Protein Structure

UniProt Annotation

Function

Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. {ECO:0000269PubMed:10207026, ECO:0000269PubMed:15361859}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	67 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0018169	ribosomal S6-glutamic acid ligase activity
GO:0019788	NEDD8 ligase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008152	metabolic process
GO:0016567	protein ubiquitination
GO:0043525	positive regulation of neuron apoptotic process
GO:0045116	protein neddylation