InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MZF1

Summary

InnateDB Protein

IDBP-73546.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MZF1

Protein Name

myeloid zinc finger 1

Synonyms

MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6;

Species

Homo sapiens

Ensembl Protein

ENSP00000215057

InnateDB Gene

IDBG-73544 (MZF1)

Protein Structure

UniProt Annotation

Function

Binds to target promoter DNA and functions as trancription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development. {ECO:0000269PubMed:15541732, ECO:0000269PubMed:17851584}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Preferentially expressed in differentiating myeloid cells. Detected in osteoblasts. {ECO:0000269PubMed:15541732}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter