InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD3E

Summary

InnateDB Protein

IDBP-73619.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD3E

Protein Name

CD3e molecule, epsilon (CD3-TCR complex)

Synonyms

IMD18; T3E; TCRE;

Species

Homo sapiens

Ensembl Protein

ENSP00000354566

InnateDB Gene

IDBG-73617 (CD3E)

Protein Structure

UniProt Annotation

Function

The CD3 complex mediates signal transduction.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Immunodeficiency 18 (IMD18) [MIM:615615]: An autosomal recessive primary immunodeficiency characterized by onset in infancy or early childhood of recurrent infections. The severity is variable, encompassing both a mild immunodeficiency and severe combined immunodeficiency (SCID), resulting in early death without bone marrow transplantation in some patients. Immunologic work-up of the IMD18 SCID patients shows a T cell-negative, B cell- positive, natural killer (NK) cell-positive phenotype, whereas T- cell development is not impaired in the mild form of IMD18. {ECO:0000269PubMed:15546002, ECO:0000269PubMed:8490660}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0030159	receptor signaling complex scaffold activity
GO:0042608	T cell receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002669	positive regulation of T cell anergy
GO:0006461	protein complex assembly
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172	signal complex assembly
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0031295	T cell costimulation
GO:0032729	positive regulation of interferon-gamma production
GO:0032753	positive regulation of interleukin-4 production
GO:0033077	T cell differentiation in thymus
GO:0035556	intracellular signal transduction
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0042981	regulation of apoptotic process
GO:0045060	negative thymic T cell selection
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045879	negative regulation of smoothened signaling pathway
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0046649	lymphocyte activation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776	regulation of immune response
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0042101	T cell receptor complex
GO:0042105	alpha-beta T cell receptor complex