InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRB14

Summary

InnateDB Protein

IDBP-73835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRB14

Protein Name

growth factor receptor-bound protein 14

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263915

InnateDB Gene

IDBG-73833 (GRB14)

Protein Structure

UniProt Annotation

Function

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269PubMed:15210700, ECO:0000269PubMed:19648926}.

Subcellular Localization

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.

Disease Associations

Tissue Specificity

Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0009967	positive regulation of signal transduction
GO:0050900	leukocyte migration

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000980 SH2 domain
IPR001849 Pleckstrin homology domain
IPR015042 BPS (Between PH and SH2) domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00017
PF14633
PF00169
PF08947

PRINTS

PR00401

PIRSF

SMART

SM00314
SM00252
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt