Homo sapiens Gene: GRB14
Summary
InnateDB Gene IDBG-73833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRB14
Gene Name growth factor receptor-bound protein 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115290
Encoded Proteins
growth factor receptor-bound protein 14
growth factor receptor-bound protein 14
growth factor receptor-bound protein 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:164492812-164621848
Strand Reverse strand
Band q24.3
Transcripts
ENST00000263915 ENSP00000263915
ENST00000446413 ENSP00000416786
ENST00000424693 ENSP00000401702
ENST00000488342
ENST00000497306
ENST00000469573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0009967 positive regulation of signal transduction
GO:0050900 leukocyte migration
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Tie2 Signaling pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Angiopoietin receptor Tie2-mediated signaling
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.411881
RefSeq NM_004490 XM_006712457
HUGO
OMIM
CCDS CCDS2222
HPRD 03313
IMGT
EMBL
GenPept
RNA Seq Atlas