Version 5.4
| Homo sapiens Protein: STARD8 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-74018.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | STARD8 | ||||||||
| Protein Name | StAR-related lipid transfer (START) domain containing 8 | ||||||||
| Synonyms | ARHGAP38; DLC3; STARTGAP3; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000363725 | ||||||||
| InnateDB Gene | IDBG-74012 (STARD8) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1. {ECO:0000269PubMed:17976533}. | ||||||||
| Subcellular Localization | Cell junction, focal adhesion {ECO:0000269PubMed:17976533}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Widely expressed with highest levels in kidney, lung and placenta. {ECO:0000269PubMed:17297465}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000198
Rho GTPase-activating protein domain IPR002913 START domain IPR008936 Rho GTPase activation protein |
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| PFAM |
PF00620
PF01852 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00324
SM00234 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q92502 | ||||||||
| PhosphoSite | PhosphoSite-Q92502 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 9754 | ||||||||
| UniGene | Hs.95140 | ||||||||
| RefSeq | NP_001135976 | ||||||||
| HUGO | HGNC:19161 | ||||||||
| OMIM | 300689 | ||||||||
| CCDS | CCDS14390 | ||||||||
| HPRD | 06730 | ||||||||
| IMGT | |||||||||
| EMBL | AK291747 AL360076 BC035587 CH471132 CR749411 D80011 | ||||||||
| GenPept | AAH35587 BAA11506 BAF84436 CAH18253 CAI41586 EAX05374 EAX05375 | ||||||||