Version 5.4
Mus musculus Protein: Cx3cr1
Summary
InnateDB Protein IDBP-742084.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cx3cr1
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000136413
InnateDB Gene IDBG-204952 (Cx3cr1)
Protein Structure
UniProt Annotation
Function Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0016495 C-X3-C chemokine receptor activity
Biological Process
GO:0002282 microglial cell activation involved in immune response
GO:0007155 cell adhesion
GO:0007186 G-protein coupled receptor signaling pathway
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0021795 cerebral cortex cell migration
GO:0030336 negative regulation of cell migration
GO:0045766 positive regulation of angiogenesis
GO:0048246 macrophage chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0016021 integral component of membrane
GO:0032809 neuronal cell body membrane
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1333815
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR005384 Duffy antigen/chemokine receptor
IPR005387 CX3C chemokine receptor 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR00657
PR01559
PR01562
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0D9
PhosphoSite PhosphoSite-Q9Z0D9
TrEMBL Q543X3
UniProt Splice Variant
Entrez Gene 13051
UniGene Mm.44065
RefSeq
MGI ID
MGI Symbol Cx3cr1
OMIM
CCDS CCDS40806
HPRD
IMGT
EMBL AF074912 AF102269 AK044557 AK137388 AK140010 BC012653 CH466587 DQ360291 DQ360292
GenPept AAC72408 AAD08665 AAH12653 ABC95973 ABC95975 BAC31979 BAE23340 BAE24210 EDL09189

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca