Mus musculus Gene: Cx3cr1
Summary
InnateDB Gene IDBG-204952.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cx3cr1
Gene Name chemokine (C-X3-C) receptor 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000052336
Encoded Proteins
chemokine (C-X3-C) receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168329:
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:119901616-120068283
Strand Reverse strand
Band F4
Transcripts
ENSMUST00000064165 ENSMUSP00000063986
ENSMUST00000177637 ENSMUSP00000136413
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016495 C-X3-C chemokine receptor activity
Biological Process
GO:0002282 microglial cell activation involved in immune response
GO:0007155 cell adhesion
GO:0007186 G-protein coupled receptor signaling pathway
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0021795 cerebral cortex cell migration
GO:0030336 negative regulation of cell migration
GO:0045766 positive regulation of angiogenesis
GO:0048246 macrophage chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0016021 integral component of membrane
GO:0032809 neuronal cell body membrane
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR ligand binding pathway
Class A/1 (Rhodopsin-like receptors) pathway
Chemokine receptors bind chemokines pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.44065
RefSeq NM_009987
OMIM
CCDS CCDS40806
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas