InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cx3cr1

Summary

InnateDB Gene

IDBG-204952.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cx3cr1

Gene Name

chemokine (C-X3-C) receptor 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052336

Encoded Proteins

IDBP-204954

chemokine (C-X3-C) receptor 1

IDBP-742084

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168329:
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:119901616-120068283

Strand

Reverse strand

Band

Transcripts

ENSMUST00000064165	ENSMUSP00000063986
ENSMUST00000177637	ENSMUSP00000136413

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016495	C-X3-C chemokine receptor activity

Biological Process

GO:0002282	microglial cell activation involved in immune response
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0021795	cerebral cortex cell migration
GO:0030336	negative regulation of cell migration
GO:0045766	positive regulation of angiogenesis
GO:0048246	macrophage chemotaxis
GO:0070098	chemokine-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand